DNA-templated supramolecular synthesis of polymers

We are developing a new class of three-dimensional precision polymers. The unique wireframe topology of these hollow polymers open new possibilities in a number of applications including as solubilizing agents, as molecular and imaging probes, and as encapsulating and delivery agents. A unique aspect of the wireframe polymers is their templated synthesis. The approach employs predictive supramolecular strategies to template the position of each monomer on a DNA nanostructure. Subsequent coupling of the monomers yields the final desired macromolecule in one pot. The modularity of the templated approach will facilitate tuning of the polymer’s size, topology, and functional groups to match the needs of the intended applications.